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WebIn this work, using cultured cardiomyocytes and a histone infusion mouse model, we demonstrate that clinically relevant histone concentrations cause significant increases in intracellular calcium concentrations with subsequent activation and enriched localization of calcium-dependent protein kinase C (PKC) α and βII into the myofilament fraction of … WebJan 13, 2012 · Measuring the in vivo levels of incorporated mutant and WT cTnI, and their basal phosphorylation levels by top-down mass spectrometry demonstrated: 1) a … pronounce behrendt
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WebDec 12, 2024 · Recent in vitro studies have demonstrated that matrix metalloprotease-2 is capable of cleaving recombinant peptides that correspond to AARs 1–77 and 135–209 of … Web5心力衰竭（HF）. HF是引起cTnI升高的常见原因之一。HF时血肌钙蛋白水平升高的可能机制包括①冠状动脉血流变化及心室重构导致氧供减少，造成心肌缺血损伤，导致cTnI的释放；②心肌细胞膜完整性的破坏以及心肌细胞的凋亡也是cTnl升高的机制。 WebMay 9, 2024 · It has been argued that, in contrast to some cTnI assays, cTnT continues to be detected even as small fragments, because the epitopes detected (aa 125–131 and aa 136–147) are centrally located and close together. 4 However, a similar situation exists for the hs-cTnI assay, 5 which uses antibodies that detect epitopes in the stable, centrally … pronounce behymer