WebJan 23, 2024 · The trial’s primary end points were PFS, and the secondary end points were objective response rate (ORR), disease control rate (DCR), time to response (TTR), duration of response (DOR), overall survival, and safety. At the data cutoff, the minimum follow up was 21.5 months. WebJul 5, 2024 · Grade 3 or higher adverse events (AEs) occurred in 69.5% of patients; the most commonly observed Grade ≥3 AEs occurring in ≥ 5% of patients were anaemia (10.5%), diarrhoea (9.5%), nausea (8.4%), large intestinal obstruction (6.3%), and acute kidney injury (5.3%).
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WebAug 6, 2024 · Recently, in another Phase II trial, apatinib (500 mg, oral, days 1–21) combined with XELOX (oxaliplatin 130 mg/m 2 intravenous injection day 1, capecitabine 1,000 mg oral days 1–14) has been assigned to treat end-stage CRC patients as a first-line therapy. The treatment cycle is every three weeks till PD or intolerance of drug toxicity … WebSep 7, 2024 · In the overall subset of patients with KRAS G12C-mutated CRC evaluated in this study, adagrasib was found to be well-tolerated as a monotherapy and in … budget accommodation anchorage
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WebSep 20, 2024 · EPOCH is a randomized phase III clinical trial evaluating TARE in patients with metastatic colorectal carcinoma of the liver who have progressed on first-line chemotherapy. The Protocol (online only) was approved by the Food and Drug Administration (FDA) under an investigational device exemption. WebSep 30, 2024 · The BEACON CRC (Binimetinib, Encorafenib, and Cetuximab Combined to Treat BRAF -Mutant Colorectal Cancer) trial is a global, multicenter, randomized, open … WebSep 22, 2015 · In the phase 3 double-blind RECOURSE study, 800 patients with refractory mCRC were randomized two-to-one to receive best supportive care plus Lonsurf (534 patients) or placebo (266 patients). The median age of patients was 63 years and the majority (60-63 percent) received at least four prior lines of therapy. budget accommodation around portland me